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Development History

History of Cardiac Net Development

researchBackground of

  • 01At a certain point, for patients who have repeated exacerbations of heart failure after unsuccessful drug therapy, heart transplantation is the only treatment option left.
  • 02However, only a limited number of patients can actually undergo heart transplantation, and in many cases an assisted artificial heart is used during the waiting period, but it is associated with complications such as blood clots and infection.
  • 03It is desirable to develop alternative/combination therapies other than drugs that are effective in reducing cardiac dilatation and the progression of heart failure, and that can be widely applied.
  • 04The development of medical devices for alternative and combination therapies has been conducted in the U.S. and Europe to date, but none have been put into practical use.
  • 05The iCorNet Institute has focused on cardiac remodeling as the root cause of heart failure exacerbations, and has been researching and developing therapeutic tools that effectively suppress remodeling itself.
    Although it is known from previous studies that the method of wrapping the heart with a net has a certain effect, it has also been found that the method of simply compressing the ventricular area with equal force impairs the diastolic function of the right ventricle and does not improve heart failure.

Tailor-made method heart assist net
solves these problems.
newTreatment of Dilated Cardiomyopathy

心不全ステージ(AHA/ACC)分類と治療法・米国での患者数 [ NYHA分類 IV 末期心不全 最大限の内科治療安静でも著明な症状(+) 20万人 心臓移植・補助心臓装置・ホスピス 確立した心不全状態 心臓アシストネット 45歳以上の割合 0.2% ] [ NYHA分類 III II I C 症候性心不全心臓の構造障害 息切れ・易疲労感・運動能低下 500万人 確立した心不全状態 心臓アシストネット 45歳以上の割合 12% ] [ B 無症候性心不全状態 心筋梗塞既往・左室収縮能低下 無症候性弁膜症(大動脈弁狭窄症・僧帽弁閉鎖不全等) 800~1000万人 薬物治療 45歳以上の割合 34% ] [ A 心不全発症高リスク群 高血圧・狭心症・糖尿病・心筋症家族歴 5000~6000万人 薬物治療 45歳以上の割合 22% ] [ 正常 45歳以上の割合 32% ] (Mann:Heart Failure 2nd ed.)

personalized system
Cardiac Assist Net
Overview and Features

  • 013D heart modeling from patient heart images
  • 02Creation of computerized knitting machine patterns from 3D heart models
  • 03Design that uses simulation technology to predict cardiac function and energy efficiency when a cardiac assist net is worn, and optimizes the net shape and physical properties.
    →Corresponds to diurnal variation in circulating blood volume
    →Able to determine patient suitability and predict postoperative cardiac function
  • 04 A computer-controlled, seamless knitting machine knits 3D shaped nets without sewing.
    →No intraoperative adjustments are required by weaving the cardiac assist net based on the patient's cardiac imaging data in advance.
    →Minimally invasive (shorter surgery time, small incision approach)
  • 05Avoids right ventricular dilatation defects
    →Sufficient compression setting for left ventricle
    →Certain prevention of cardiac remodeling
[テーラーメイド方式心臓アシストネット] [右室拘束軽減ネット臨床研究]

Tested Products and Developed TechnologiesOverview of

心臓MRI画像断面から 心臓壁抽出 (拡張期、収縮期)

3D heart
Model Creation

心臓カテーテル検査(RV&LV) 心機能シミュレーション:LVEDP10~30mmHgで、左心室表面着圧が0~15mmHg になるようにネット形状・物性を設計

Heart shape data and
Fusion of pressure data

Systole(収縮期) [LV ESP 102mmHg][ESV 195ml][RV ESP 45mmHg][ESV 187ml][心臓容積 738ml][心室壁容積 355ml] Diastole(拡張期) [LV ESP 35mmHg][EDV 249ml][RV ESP 20mmHg][EDV 232ml][心臓容積 840ml][心室壁容積 359ml]
心臓凹凸を補正し、ネット形状で座標計算

Thread count adjustment (net physical properties database)

コンピュータ編み機基本型紙 ネット製造
[テイラーメイド 右室穴あきネット 術中調整が不要                             ⇒低侵襲(手術時間短縮)                            日内変動に対応                             ⇒QOL改善、心臓リモデリング防止し、右室壁運動が                                  維持される                             ⇒心拍出量が維持、運動能改善]                            [高頻度刺激による慢性心不全犬モデルでの心臓ネット植え込み実験:                            右室拘束軽減型ネットで両心室収縮(Emax)が最も改善される。]

Thus, each patient's
To match individual image data
To create a tailor-made net,
After the image data is provided.
It takes about one month to complete.

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About the Cardiac Support Net treatment and,
Clinical trials, etc.
Please feel free to contact us for any inquiries.

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